In Sequence | July 22, 2008

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Volume 2 - Number 30 | July 22, 2008

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In This Week's Issue

Three Pharma Giants Bankroll Newcomer To Develop PGx Tools for Drug Discovery

Exact Disappoints Investors With Cost Restructuring Plan; Seeks M&A Partner

Study Confirms Gene Panel Predicts Lung Cancer Survival, But Urges Caution on Dx

Illumina, Avantome, Roche, Metabolon, UT Health Science Center, FDA, Response Biomedical, NY State Department of Health, Rosetta Genomics, Cellumen, Cernostics Pathology, Celera, Toyota Tsusho America, Nippon Kayaku

Joseph Hogan, John Dineen, Jim Doyle, James Dahlberg, Katherine Napier, Gordon Brunner, David Thompson, Glenn Muir, Robert Cascella, Mark Casey, Stuart Kingsley, Howard Doran

Features

Bio-Reference Laboratories� GeneDx to Launch Genetic Test Based on Illumina GA This Fall
The homebrew test, currently in early-access testing and scheduled to be launched in October, is among the first commercial diagnostic tests to be offered on a next-generation sequencing platform. Though not the first genetic test for hypertrophic cardiomyopathy, the company claims it will be less expensive than rival assays. It is the first of many tests that GeneDx plans to offer on the Illumina GA.

New Base Caller Improves Accuracy of Long Illumina Reads; May Allow De Novo Assembly
Using Alta-Cyclic, which the CSHL researchers described online in Nature Methods this month, they were able to increase the number of accurate 78-base reads in a run from 5 percent to 22 percent. These reads, they say, may allow them to assemble complex eukaryotic genomes de novo.

Papers of Note

Transcript

Tim Hubbard On Sequence Databases, Ensembl, ENCODE, and More
Tim Hubbard is head of informatics and of human genome analysis at the Wellcome Trust Sanger Institute. He is involved with the Ensembl project and the ENCyclopedia Of DNA Elements project, and has roles in the Genome Reference Consortium and the International Cancer Genome Consortium. He recently spoke to In Sequence about where these projects are headed.

Short Reads

Illumina, Avantome, Roche, 454 Life Sciences, Applied Biosystems, InteRNA Genomics, Biotique Systems, Genomatix Software, BioTeam, Invitrogen, Active Motif, Genetic Technologies, LabCorp, 23andMe, Oxford Biomedical Research Centre, International Genomics Consortium, LabVantage, NHGRI, US Department of Agriculture, NIH, US Genomics

New Products

SOLiD Software Analysis Tools, GenomeQuest 5.0, Metagenomic DNA Isolation Kit

Paired Ends

Steven Pinker, Stephen Pentoney, Joseph Hogan